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John G Krolikowski Selected Research

Isoflurane

2/2009Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
12/2006Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.
8/2006Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase.
5/2006Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo.
5/2006The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits.
2/2006Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo.
12/2005Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels.
10/2005Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits.
7/2005Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium.
1/2005Isoflurane protects against myocardial infarction during early reperfusion by activation of phosphatidylinositol-3-kinase signal transduction: evidence for anesthetic-induced postconditioning in rabbits.
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John G Krolikowski Research Topics

Disease

27Infarction (Infarctions)
10/2009 - 01/2002
25Myocardial Infarction
10/2009 - 01/2002
11Ischemia
12/2021 - 11/2002
10Coronary Occlusion
02/2009 - 03/2004
5Hyperglycemia
04/2008 - 01/2002
5Reperfusion Injury
08/2006 - 03/2004
3Myocardial Ischemia (Ischemic Heart Diseases)
01/2005 - 11/2002
2Necrosis
12/2021 - 04/2009
1Hyperoxia
01/2019
1Fibrosis (Cirrhosis)
01/2016
1Inflammation (Inflammations)
01/2016
1Vasculitis (Vasculitides)
09/2013
1Systemic Scleroderma (Systemic Sclerosis)
03/2011
1Acidosis
04/2009
1Alkalosis
04/2009
1B-Cell Lymphoma (Lymphoma, B Cell)
05/2006
1Respiratory Insufficiency (Respiratory Failure)
11/2004
1Experimental Diabetes Mellitus
08/2004
1Diabetes Mellitus
06/2002

Drug/Important Bio-Agent (IBA)

22triphenyltetrazoliumIBA
12/2021 - 01/2002
18IsofluraneFDA LinkGeneric
02/2009 - 01/2002
8Anesthetics (Anesthetic Agents)IBA
09/2007 - 01/2002
6Saline SolutionIBA
04/2009 - 06/2003
5HeliumIBA
10/2009 - 08/2008
5Adenosine Triphosphate (ATP)IBA
08/2008 - 01/2002
4AtractylosideIBA
09/2008 - 12/2005
4WortmanninIBA
09/2007 - 01/2005
3Cyclosporine (Ciclosporin)FDA LinkGeneric
04/2009 - 12/2005
3arginine methyl esterIBA
02/2009 - 07/2005
3Nitric Oxide (Nitrogen Monoxide)FDA Link
09/2008 - 08/2006
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
05/2006 - 12/2005
3Blood Glucose (Blood Sugar)IBA
08/2004 - 06/2002
2LipidsIBA
01/2021 - 11/2004
2Morphine (MS Contin)FDA LinkGeneric
10/2009 - 10/2005
2Opioid Receptors (Opioid Receptor)IBA
10/2009 - 10/2005
2Naloxone (Narcan)FDA LinkGeneric
10/2009 - 10/2005
2Mitochondrial Permeability Transition PoreIBA
04/2009 - 05/2006
2Nitric Oxide Synthase (NO Synthase)IBA
02/2009 - 09/2008
2NG-Nitroarginine Methyl Ester (L-NAME)IBA
09/2008 - 08/2006
2Reactive Oxygen Species (Oxygen Radicals)IBA
08/2008 - 06/2003
2Potassium Channels (Potassium Channel)IBA
08/2008 - 01/2002
2Phosphotransferases (Kinase)IBA
09/2007 - 02/2006
2Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
08/2006 - 02/2006
2Proteins (Proteins, Gene)FDA Link
08/2006 - 05/2006
2barbituric acid (barbiturate)IBA
02/2006 - 03/2004
2Glucose (Dextrose)FDA LinkGeneric
08/2004 - 06/2003
2Celecoxib (Celebrex)FDA Link
03/2004 - 03/2004
2Ethanol (Ethyl Alcohol)IBA
04/2003 - 04/2002
1phospholipid emulsion soybean oil (Intralipid)IBA
01/2021
1EmulsionsIBA
01/2021
1Peptides (Polypeptides)IBA
01/2016
1MetalsIBA
09/2013
1IonsIBA
09/2013
1Fibrillin-1IBA
03/2011
1Oxygen (Dioxygen)IBA
04/2009
1Sodium Bicarbonate (Baking Soda)FDA LinkGeneric
04/2009
1monorden (radicicol)IBA
02/2009
1geldanamycinIBA
02/2009
1Simvastatin (Zocor)FDA LinkGeneric
04/2008
1Sildenafil Citrate (Viagra)FDA Link
12/2007
1Noble Gases (Rare Gases)IBA
09/2007
1Sirolimus (Rapamycin)FDA Link
09/2007
12- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA
09/2007
1pifithrinIBA
12/2006
1Estrogens (Estrogen)FDA Link
08/2006
1ethyl 2- amino- 6- bromo- 4- (1- cyano- 2- ethoxy- 2- oxoethyl)- 4H- chromene- 3- carboxylateIBA
05/2006
1Glycogen Synthase KinasesIBA
05/2006
1SB 216763IBA
05/2006
170-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
02/2006
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
02/2006
15-hydroxydecanoic acidIBA
12/2005
1Narcotic Antagonists (Opioid Antagonists)IBA
10/2005
1Cytochromes c (Cytochrome c)IBA
10/2005
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
10/2005
17-nitroindazoleIBA
07/2005
1pimagedine (aminoguanidine)IBA
07/2005
1Pentobarbital (Nembutal)FDA Link
01/2005
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
01/2005
1Sevoflurane (Ultane)FDA LinkGeneric
11/2004
1Enflurane (Ethrane)FDA LinkGeneric
11/2004
1Streptozocin (Streptozotocin)FDA Link
08/2004
1Glyburide (Glibenclamide)FDA LinkGeneric
08/2004
1PotassiumIBA
08/2004
1Insulin (Novolin)FDA Link
08/2004
1KATP ChannelsIBA
08/2004
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
03/2004
1Acetaminophen (Paracetamol)FDA LinkGeneric
03/2004
1Diazoxide (Hyperstat)FDA Link
03/2004
1mitochondrial K(ATP) channelIBA
03/2004
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
03/2004
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
03/2004
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
03/2004
1Acetylcysteine (Siran)FDA LinkGeneric
06/2003
1Adenosine (Adenocard)FDA LinkGeneric
04/2003

Therapy/Procedure

8Microspheres (Microsphere)
12/2007 - 01/2002
3Ischemic Postconditioning
04/2009 - 01/2005
1Tourniquets
12/2021
1Lasers (Laser)
12/2021
1Electrodes (Electrode)
01/2019